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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
30/08/2022 |
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Actualizado : |
30/08/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
CARRACELAS, B.; NAVAJAS, E.; VERA, B.; CIAPPESONI, G. |
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Afiliación : |
EMERITA BEATRIZ CARRACELAS MARQUEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; BRENDA VERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Genome-wide association study of parasite resistance to gastrointestinal nematodes in Corriedale sheep. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Genes, 2022, vol. 13, issue 9, 1548. OPEN ACCESS. doi: https://doi.org/10.3390/genes13091548 |
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ISSN : |
e-ISSN 2073-4425 |
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DOI : |
10.3390/genes13091548 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 25 May 2022; Revised 19 August 2022; Accepted 23 August 2022; Published 27 August 2022.
Correspondence: gciappesoni@inia.org.uy -- Academic Editor: Qiuyue Liu.
License: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
This article belongs to the Collection Feature Papers in Animal Genetics and Genomics: https://www.mdpi.com/journal/genes/topical_collections/feature_paper_animal |
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Contenido : |
ABSTRACT.- Selection of genetically resistant animals is one alternative to reduce the negative impact of gastrointestinal nematodes (GIN) on sheep production. The aim of this study was to identify genomic regions associated with GIN resistance in Corriedale sheep by single-step genome-wide association studies (ssGWAS) using 170, 507 and 50K single nucleotide polymorphisms (SNPs). Analysis included 19,547 lambs with faecal egg counts (FEC) records, a pedigree file of 40,056 animals and 454, 711 and 383 genotypes from 170, 507 and 50K SNPs, respectively. Genomic estimated breeding values (GEBV) were obtained with single-step genomic BLUP methodology (ssGBLUP), using a univariate animal model, which included contemporary group, type of birth and age of dam as class fixed effects and age at FEC recording as covariate. The SNP effects as wells as p-values were estimated with POSTGSF90 program. Significance level was defined by a chromosome-wise False Discovery Rate of 5%. Significant genomic regions were identified in chromosomes 1, 3, 12 and 19 with the 170 SNP set, in chromosomes 7, 12 and 24 using the 507 SNP chip and only in chromosome 7 with the 50K SNP chip. Candidate genes located in these regions, using Oar_v4.0 as reference genome, were TIMP3, TLR5, LEPR and TLR9 (170 SNPs), SYNDIG1L and MGRN1 (507 SNP chip) and INO80, TLN2, TSHR and EIF2AK4 (50K SNP chip). These results validate genomic regions associated with FEC previously identified in Corriedale and other breeds and report new candidate regions for further investigation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. MenosABSTRACT.- Selection of genetically resistant animals is one alternative to reduce the negative impact of gastrointestinal nematodes (GIN) on sheep production. The aim of this study was to identify genomic regions associated with GIN resistance in Corriedale sheep by single-step genome-wide association studies (ssGWAS) using 170, 507 and 50K single nucleotide polymorphisms (SNPs). Analysis included 19,547 lambs with faecal egg counts (FEC) records, a pedigree file of 40,056 animals and 454, 711 and 383 genotypes from 170, 507 and 50K SNPs, respectively. Genomic estimated breeding values (GEBV) were obtained with single-step genomic BLUP methodology (ssGBLUP), using a univariate animal model, which included contemporary group, type of birth and age of dam as class fixed effects and age at FEC recording as covariate. The SNP effects as wells as p-values were estimated with POSTGSF90 program. Significance level was defined by a chromosome-wise False Discovery Rate of 5%. Significant genomic regions were identified in chromosomes 1, 3, 12 and 19 with the 170 SNP set, in chromosomes 7, 12 and 24 using the 507 SNP chip and only in chromosome 7 with the 50K SNP chip. Candidate genes located in these regions, using Oar_v4.0 as reference genome, were TIMP3, TLR5, LEPR and TLR9 (170 SNPs), SYNDIG1L and MGRN1 (507 SNP chip) and INO80, TLN2, TSHR and EIF2AK4 (50K SNP chip). These results validate genomic regions associated with FEC previously identified in Corriedale and other breeds an... Presentar Todo |
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Palabras claves : |
FEC; Genomic regions; SsGWAS. |
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Asunto categoría : |
L01 Ganadería |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16636/1/genes-13-01548-v2.pdf
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Marc : |
LEADER 02850naa a2200229 a 4500
001 1063548
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008 2022 bl uuuu u00u1 u #d
022 $ae-ISSN 2073-4425
024 7 $a10.3390/genes13091548$2DOI
100 1 $aCARRACELAS, B.
245 $aGenome-wide association study of parasite resistance to gastrointestinal nematodes in Corriedale sheep.$h[electronic resource]
260 $c2022
500 $aArticle history: Received 25 May 2022; Revised 19 August 2022; Accepted 23 August 2022; Published 27 August 2022. Correspondence: gciappesoni@inia.org.uy -- Academic Editor: Qiuyue Liu. License: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). This article belongs to the Collection Feature Papers in Animal Genetics and Genomics: https://www.mdpi.com/journal/genes/topical_collections/feature_paper_animal
520 $aABSTRACT.- Selection of genetically resistant animals is one alternative to reduce the negative impact of gastrointestinal nematodes (GIN) on sheep production. The aim of this study was to identify genomic regions associated with GIN resistance in Corriedale sheep by single-step genome-wide association studies (ssGWAS) using 170, 507 and 50K single nucleotide polymorphisms (SNPs). Analysis included 19,547 lambs with faecal egg counts (FEC) records, a pedigree file of 40,056 animals and 454, 711 and 383 genotypes from 170, 507 and 50K SNPs, respectively. Genomic estimated breeding values (GEBV) were obtained with single-step genomic BLUP methodology (ssGBLUP), using a univariate animal model, which included contemporary group, type of birth and age of dam as class fixed effects and age at FEC recording as covariate. The SNP effects as wells as p-values were estimated with POSTGSF90 program. Significance level was defined by a chromosome-wise False Discovery Rate of 5%. Significant genomic regions were identified in chromosomes 1, 3, 12 and 19 with the 170 SNP set, in chromosomes 7, 12 and 24 using the 507 SNP chip and only in chromosome 7 with the 50K SNP chip. Candidate genes located in these regions, using Oar_v4.0 as reference genome, were TIMP3, TLR5, LEPR and TLR9 (170 SNPs), SYNDIG1L and MGRN1 (507 SNP chip) and INO80, TLN2, TSHR and EIF2AK4 (50K SNP chip). These results validate genomic regions associated with FEC previously identified in Corriedale and other breeds and report new candidate regions for further investigation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
653 $aFEC
653 $aGenomic regions
653 $aSsGWAS
700 1 $aNAVAJAS, E.
700 1 $aVERA, B.
700 1 $aCIAPPESONI, G.
773 $tGenes, 2022, vol. 13, issue 9, 1548. OPEN ACCESS. doi: https://doi.org/10.3390/genes13091548
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Registro original : |
INIA Las Brujas (LB) |
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| Registros recuperados : 28 | |
| 5. |  | CARRACELAS, B.; NAVAJAS, E.; VERA, B.; CIAPPESONI, G. Estudio de asociación de genoma completo para resistencia genética a nematodos gastrointestinales en ovinos Corriedale. [abstract]. In: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Una Sola Salud (Single Health Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.96. (Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1) Corresponding author: B. Carracelas, Instituto Nacional de Investigación Agropecuaria (INIA), Ruta 48 Km 10, Las Brujas, Uruguay, mailto: bcarracelas@inia.org.uy| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 9. | | CARRACELAS, B.; NAVAJAS, E.; VERA, B.; CIAPPESONI, G. SNP arrays evaluation as tools in genetic improvement in Corriedale sheep in Uruguay. [Evaluación de paneles de SNP como herramientas en la mejora genética de ovinos Corriedale en Uruguay]. [Avaliação de painéis de SNP como ferramentas em melhoramento genético de ovinos Corriedale no Uruguai]. Animal production and pastures. Agrociencia Uruguay, 2022, vol. 26, number 2, article e998. doi: https://doi.org/10.31285/AGRO.26.998 Article history: Received 09 Feb 2022; Accepted 30 May 2022; Published 19 Aug 2022. Editor: Mariana Carriquiry, Universidad de la República, Facultad de Agronomía, Montevideo, Uruguay. Correspondence: Beatriz Carracelas,...| Tipo: Artículos en Revistas Indexadas Nacionales | Circulación / Nivel : Nacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 10. | | VERA, B.; DE BARBIERI, I.; FERREIRA, G.; NAVAJAS, E.; CARRACELAS, B.; CIAPPESONI, G. Asignación de parentesco y detección de superfecundación heteropaternal en ovinos Merino Australiano mediante paneles de SNP. In: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Cambio Climático y Producción Sostenible (Climate Change Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.85-87. (Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1) Corresponding author: B. Vera, Instituto Nacional de Investigación Agropecuaria (INIA), Ruta 48 km 10, Las Brujas (Uruguay), mailto: bvera@inia.org.uy| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Las Brujas. |
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| 13. | | MEDEROS, A.; GALARRAGA, D.; CARRACELAS, B.; PIMENTEL, S.; LOPEZ, F.; MORENO, L.; BOVE, R. Campylobacteriosis genital bovina: importancia del monitoreo previo al entore. Revista INIA, 2014, no. 38, p. 16-20| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Tacuarembó. |
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| 14. | | MEDEROS, A.; CARRACELAS, B.; MINHO, A.P.; FERNÁNDEZ, S.; SÁNCHEZ, J. Prevalence and Factors Associated with Anthelmintic Resistance in Gastrointestinal Nematodes of Cattle: A Systematic Review and Meta-analysis. Journal of Veterinary Medicine and Health, v. 2, no. 2, 2018. OPEN ACCESS. Article history: Received November 21, 2018; Accepted December 02, 2018; Published December 17, 2018.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Tacuarembó. |
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| 15. | | CIAPPESONI, G.; NAVAJAS, E.; BAPTISTA, R.; AGUILAR, I.; PERAZA, P.; CARRACELAS, B.; DE BARBIERI, I. Proyecto SMARTER. INIA ya está en el Mundial de la Genética Ovina. Producción Animal. Revista INIA Uruguay, Marzo 2022, no.68, p.15-18. (Revista INIA; 68).| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Las Brujas. |
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| 16. | | VERA, B.; MONZALVO, C.; NAVAJAS, E.; DE BARBIERI, I.; CARRACELAS, B.; VAN LIER, E.; CIAPPESONI, G. Predicción del valor genético de ovinos en predios comerciales para emisión de metano, eficiencia de conversión y características productivas. Revista INIA Uruguay, Diciembre 2022, no.71, p. 34-37. (Revista INIA; 71)| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Treinta y Tres. |
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| 17. | | MEDEROS, A.; BANCHERO, G.; MONTOSSI, F.; ISASA, F.; CARRACELAS, B.; CRUDELI, M. Uso de extractos de taninos de quebracho (Shinopsis Spp) en el control de parásitos gastrointestinales de los ovinos en pastoreo. ln: INIA Tacuarembó. Unidad Experimental Glencoe. Día de Campo Unidad Experimental Glencoe [Colonia Fernando Baccaro, Guarapirú, Paysandú], 2012. Propuestas tecnológicas para sistemas ganaderos de Basalto. Tacuarembó (Uruguay): INIA, 2012. p. 18-20 (INIA Serie Actividades de Difusión ; 693)| Biblioteca(s): INIA Tacuarembó. |
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| 18. | | MEDEROS, A.; GALARRAGA, D.; CARRACELAS, B.; PIMENTEL, J.; MORENO, L.; ALVEZ, A.; BOVE, R.; LÓPEZ, F.; PERERA, C. Diagnóstico y control de Campylobacteriosis genital bovina. In: Seminario de Actualización Técnica: Entore planificado: +terneros+$ (2015, Tacuarembó, Uruguay), [Presentación oral] UY, INIA Tacuarembó. 23 de Octubre 2015.| Tipo: Presentaciones Orales |
| Biblioteca(s): INIA Tacuarembó. |
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| 19. | | CARRACELAS, B.; PERAZA, P.; VERGARA, A.; CIAPPESONI, G.; RAVAGNOLO, O.; AGUILAR, I.; LEMA, O.M.; NAVAJAS, E. Banco de ADN genómico animal - plataforma de evaluación genómica. Revista INIA Uruguay, Diciembre 2022, no.71, p. 38-42. (Revista INIA; 71)| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Treinta y Tres. |
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| 20. | | RUGGIA, A.; CARRACELAS, B.; CIAPPESONI, G.; DEL PINO, M.L.; DEVINCENZI, T.; MONTALDO, S.; CARRIQUIRY, M.; NAVAJAS, E. Núcleo Informativo Hereford de INIA Las Brujas. Anuario Hereford (Montevideo), 2020, p. 214-215.| Biblioteca(s): INIA La Estanzuela; INIA Tacuarembó. |
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| Registros recuperados : 28 | |
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